Voici les acteurs découvert tout au long de la série:
Lucas Scott => Chad Michael Murray (2003-2009)
Nathan Scott => James Lafferty
Brooke Davis => Sophia Bush
Peyton Sawyer => Hilarie Burton (2003-2009)
Haley James Scott => Bethany Joy Galeotti
Marvin/ Mouth (Micro) McFadden => Lee Norris
Rachel Gattina => Danneel Harris (2005-2008 et 2009-2010)
Skills Taylor => Antwon Tanner
Keith Scott => Craig Sheffler (2003-2006)
Dan Scott => Paul Johansson
Karen Roe => Moira Kelly
Deborah Scott => Barbara Alyn Woods
Whitey Durham => Barry Corbin
Millicent Huxtable => Lisa Goldstein
Victoria Davis => Daphne Zuniga
Jamie Scott => Jackson Brundage
Mia Catalano => Kate Voegele
Julian Baker => Austin Nichols
Quinn James => Shantel Van Santen
Clay Evans => Robert Buckley
Alex Dupre => Jana Kramer